The Uruzgan-Kandahar highway was reopened for traffic on Saturday, after a week of closure, an official said.
The highway had been closed by militants and security forces in the Khakrez district of Kandahar province.
Abdul Rahim, a transport official, said the militants had told drivers that they could use the highway.
He added patients, passengers and other needy people could travel the Kajoor highway during the closure. They traveled nine hours while the highway takes four and a half hours.
Niamatullah, a resident of Tirnikot, said the price of a 10-litre cane of ghee had jumped to 2,000 rupees from 1,100 rupees due to the highway closure.