The Pashtun Tahafuz Movement (PTM) has called for the immediate release of its activists, including a lawmaker.
PTM chief Manzoor Pashteen issued the call at a massive public meeting in the Bara tehsil of Khyber tribal district.
Ali Wazir, a party member of the National Assembly, and several workers of the group have been detained in different parts of the country.
Wazir was arrested on Dec 17 in connection with a case registered against him in Karachi after a recent public meeting in the port city.
They PTM members were accused of committing offences, including hatching a criminal conspiracy and passing derogatory remarks against state institutions.
Pashteen also stressed the need for an end to targeted killings of innocent people in different parts of the country, particularly in Waziristan.